Unlike Paint, MyPaint doesn't require any special drivers or hardware to run - it just sits down and makes use of your current Windows system atypical of most Paint programs. What is the difference between MyPaint and Paintbrush? There are several different image-editing and sketching programs available for Windows, but MyPaint is specifically made for dedicated sketchers who need all the convenience of a Paint-style program while still left with the ability to paint in layers and multiple colors.